CANdotWater soluble nanoparticles

CANdot Series covers a wide spectrum of nanoparticles with outstanding features for a broad range of applications. In particular, all CANdot ® Series are highly monodisperse and stable in aqueous media, e.g. water, buffers, serum etc.

Series A: Fluorescent cadmium-based nanoparticles with tuneable emission wavelength in the visible range (500-650nm). The core particles have diameters between 3 and 8 nm and are supplied as dispersions optionally in n-hexane or water. CANdot ® Series A provide high quantum yields and stability and can be excited by any wavelength below the emission wavelength. The biocompatible coating provides high stability in biological media with concomitant very low cytotoxicity and facile biofunctionalization, thus rendering CANdot Series A ideally suited as fluorescent markers in biomedical diagnostics.

Series C: Lead sulfide based nanoparticles for application as IR-emitter (1000 to 1600nm). These particles are offered in diameters between 3 and 6 nm and absorb in the whole visible and NIR wavelength region, making them suitable as IR-markers in biomedical research.

Series D: Copper- and manganese doped*) zinc oxide nanoparticles with antimicrobial properties. These particles are provided in a spherical or rodlike shape with defined diameters between 5 to 100nm and are available as dispersion in a water/ethylene glycol mixture. CANdot ® Series D exhibits antimicrobial effects towards various bacteria, e.g. against Staphylococcus aureus.

Series G: Plasmonic gold nanoparticles display extremely high molar extinction coefficients in the visible wavelength region for a quick and easy optical readout. These spherical particles have a narrow size distribution (CV < 10%) and are available as an aqueous dispersion in 10 nm increments from 10 to 100 nm. Due to the high affinity of their surface atoms to thiol groups, positively charged functional groups and biomolecules with positive net charge, CANdot ® Series G can be very conveniently conjugated to specific molecular probes for diagnostic purposes.

Series M: Superparamagnetic iron oxide nanoparticles with defined sizes, ranging from 5 to 25 nm. Depending on the particles size, the magnetic properties can be tuned for T1 and T2/T2* contrast as well as for optimized pharmacokinetics.

Series X: Fluorescent lanthanide doped particles with different fluorescent colours (blue, yellow, green and red) of very narrow emission bands. These particles form transparent dispersions in aqueous solutions and show very low cellular toxicity. Excitation is carried out under UV light of about 300nm.

Dr. Jan Niehaus

Dr. Jan Niehaus